Cryo-EM structure of a designed AAV8-based vector
Resolution: 2.08 Å
EM Method: Single-particle
Fitted PDBs: 8jre
Q-score: 0.699
Luo S, Jiang H, Li Q, Qin Y, Yang S, Li J, Xu L, Gou Y, Zhang Y, Liu F, Ke X, Zheng Q, Sun X
Nat Commun (2024) 15 pp. 3780-3780 [ DOI: doi:10.1038/s41467-024-48221-4 Pubmed: 38710714 ]
- Capsid protein (59 kDa, Protein from Adeno-associated virus - 8)
- Adeno-associated virus - 8 (Virus from Adeno-associated virus - 8)
AAV8 human HEK293-produced, full capsid
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6pwa
Q-score: 0.563
Rumachik NG, Malaker SA, Poweleit N, Maynard LH, Adams CM, Leib RD, Cirolia G, Thomas D, Stamnes S, Holt K, Sinn P, May AP, Paulk NK
Mol Ther Methods Clin Dev (2020) 18 pp. 98-118 [ Pubmed: 32995354 DOI: doi:10.1016/j.omtm.2020.05.018 ]
- Capsid protein (58 kDa, Protein from Adeno-associated virus - 8)
- Adeno-associated virus-8 (Virus from Adeno-associated virus-8)
AAV8 human HEK293-produced, empty capsid
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6u20
Q-score: 0.387
Rumachik NG, Malaker SA, Poweleit N, Maynard LH, Adams CM, Leib RD, Cirolia G, Thomas D, Stamnes S, Holt K, Sinn P, May AP, Paulk NK
Mol Ther Methods Clin Dev (2020) 18 pp. 98-118 [ Pubmed: 32995354 DOI: doi:10.1016/j.omtm.2020.05.018 ]
- Capsid protein (58 kDa, Protein from Adeno-associated virus - 8)
- Adeno-associated virus - 8 (Virus from Adeno-associated virus - 8)
AAV8 Baculovirus-Sf9 produced, full capsid
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6u2v
Q-score: 0.472
Rumachik NG, Malaker SA, Poweleit N, Maynard LH, Adams CM, Leib RD, Cirolia G, Thomas D, Stamnes S, Holt K, Sinn P, May AP, Paulk NK
Mol Ther Methods Clin Dev (2020) 18 pp. 98-118 [ Pubmed: 32995354 DOI: doi:10.1016/j.omtm.2020.05.018 ]
- Capsid protein (58 kDa, Protein from Adeno-associated virus - 8)
- Adeno-associated virus - 8 (Virus from Adeno-associated virus - 8)
AAV8 Baculovirus-Sf9 produced, empty capsid
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6ubm
Q-score: 0.373
Rumachik NG, Malaker SA, Poweleit N, Maynard LH, Adams CM, Leib RD, Cirolia G, Thomas D, Stamnes S, Holt K, Sinn P, May AP, Paulk NK
To Be Published
- Capsid protein (58 kDa, Protein from Adeno-associated virus - 8)
- Adeno-associated virus - 8 (Virus from Adeno-associated virus - 8)
genome-containing AAV8 particles
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 6v10
Q-score: 0.462
Mietzsch M, Barnes C, Hull JA, Chipman P, Xie J, Bhattacharya N, Sousa D, McKenna R, Gao G, Agbandje-McKenna M
J Virol (2020) 94 [ DOI: doi:10.1128/JVI.01769-19 Pubmed: 31826994 ]
- 2'-deoxycytidine-5'-monophosphate (307 Da, Ligand)
- 2'-deoxyadenosine-5'-monophosphate (331 Da, Ligand)
- Capsid protein (58 kDa, Protein from Adeno-associated virus - 8)
- Adeno-associated virus - 8 (Virus from Adeno-associated virus - 8)
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 6v12
Q-score: 0.542
Mietzsch M, Barnes C, Hull JA, Chipman P, Xie J, Bhattacharya N, Sousa D, McKenna R, Gao G, Agbandje-McKenna M
J Virol (2020) 94 [ DOI: doi:10.1128/JVI.01769-19 Pubmed: 31826994 ]
- Capsid protein (58 kDa, Protein from Adeno-associated virus - 8)
- Adeno-associated virus - 8 (Virus from Adeno-associated virus - 8)